Optimization of Catheter Based rtPA Thrombolysis in a Novel In Vitro Clot Model for Intracerebral Hemorrhage

Figure 4

(a) A dose-response relationship was evaluated in five groups each consisting of three 25 mL blood clots with five different doses of rtPA (0.5; 0.9; 1.2; 2; 3 mg): treatment group (red) and control group (black). The relative posttreatment clot weight is shown on the -axis. The differences of weight of the treated and the control blood clots showed the effect of lysis of each rtPA dose (green). The black line shows the dose-response relationship of rtPA. The arrow indicates the 95% effective dose of 1.2 ± 0.52 mg rtPA. (b) Similar to (a) a dose-response relationship was evaluated for 50 mL blood clots in five groups each consisting of three 50 mL blood clots with five different doses of rtPA (0.5; 0.9; 1.2; 2; 3 mg): treatment group (red) and control group (black). The relative posttreatment clot weight is shown on the -axis. The differences of weight of the treated and the control blood clots showed the effect of lysis of each rtPA dose (green). The black line shows the dose-response relationship of rtPA. The arrow indicates the 95% effective rtPA dose of 0.84 ± 1.07 mg rtPA.

(a)

(b)