Oxidative Stress-Induced DNA Damage by Manganese Dioxide Nanoparticles in Human Neuronal Cells

Figure 7

(a) Chromosomal condensation at 60 μg/ml for 24 and 48 h; (b) MNPs induced apoptosis as demonstrated by phosphatidylserine translocation in SH-SY5Y cells incubated with different concentrations of MNPs exposure for 24 and 48 h and stained with Annexin V and propidium iodide (PI); (c) induction of caspase-3 activity in SH-SY5Y cells after exposure to MNPs for 24 and 48 h. Each value represents the mean ± SE of three experiments. , versus control. Scale bar 10 μm.

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