Immunotherapy for Patients with Advanced Urothelial Cancer: Current Evidence and Future Perspectives

Table 3

Ongoing clinical trials of anti-CTLA-4 immune checkpoint inhibitors in metastatic urothelial cancer.

	Study	Phase	Regimen	Primary endpoints	Planned number of pts or pts enrolled	Status
Ipilimumab	NCT01524991	II	IV gemcitabine 1000 mg/m^2 d 1,8 + cisplatin 70 mg/m^2 d1 q3w. IV Ipi 10 mg/kg d1 (start c3)	1 year OS	36	Active, not recruiting
	NCT02496208	I	OS cabozantinib-s-malate + IV Niv Ipi	Safety and DLT	66	Currently recruiting
	NCT01928394	I/II	IV Niv Ipi (different schedules) cobimetinib	ORR	1150	Currently recruiting
	NCT02381314	I	IV Ipi d1 q3w + IV enoblituzumab weekly	Safety	84	Currently recruiting
	NCT02834013 (DART)	II	IV Niv d 1,15,29 + IV ipilimumab d1 q6w	ORR	334	Active, not recruiting
Tremelimumab	NCT02516241	III	IV Drv IV Trm versus CT (platinum + gemcitabine)	PFS, OS	1005	Active, not recruiting
	NCT02527434	II	IV Trm versus IV Trm + IV Drv versus IV Drv	ORR	66	Currently recruiting
	NCT02643303	I/II	IV Drv + IV tremelimumab IT/IM PolyICLC	Recommended combination dose, safety, ORR, PFS, and OS	102	Active, not recruiting