Preoperative C-Reactive Protein as a Risk Factor for Postoperative Delirium in Elderly Patients Undergoing Laparoscopic Surgery for Colon Carcinoma

Table 2

Univariate and multivariate logistic regression analyses of POD in patients with colon carcinoma undergoing laparoscopic surgery.

Variables	Univariate		Multivariate
	OR (95% CI)	P value	OR (95% CI)	P value
Age	2.87 (1.34–6.63)	0.029	1.16 (0.96–1.09)	0.46
MCCI	2.32 (1.51–3.23)	0.037	1.26 (0.49–3.12)	0.61
MMSE score	2.27 (1.14–4.67)	0.011	2.01 (0.91–4.67)	0.098
Heavy drinker	1.48 (0.89–2.53)	0.15
Operative approach	2.34 (0.81–7.22)	0.18
Operation time	2.12 (0.62–6.69)	0.29
Anesthesia time	0.97 (0.92–1.04)	0.09
Wound infection	2.83 (0.62–6.14)	0.25
Pulmonary infection	1.37 (0.76–5.19)	0.54
Cardiovascular events	1.28 (1.08–1.42)	<0.01	1.11 (0.87–1.68)	0.21
Plasma CRP levels
Preoperative	11.13 (3.51–25.29)	<0.01	5.87 (2.22–11.4)	0.018
Postoperative day 2	4.54 (1.49–13.71)	0.021	3.12 (0.75–8.27)	0.34

POD, postoperative delirium; MMSE, Mini-Mental State Examination; MCCI, Modified Charlson Comorbidity Index; CRP, C-reactive protein; OR, odds ratio; CI, confidence interval. Multivariate analysis by logistic regression, .