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BioMed Research International
Volume 2017, Article ID 5637923, 8 pages
https://doi.org/10.1155/2017/5637923
Research Article

A Higher Ovarian Response after Stimulation for IVF Is Related to a Higher Number of Euploid Embryos

1Human Reproduction Unit, Instituto Valenciano de Infertilidad (IVI), Plaza de la Policía Local 3, 46015 Valencia, Spain
2PGD Laboratory, Instituto Valenciano de Infertilidad (IVI), Plaza de la Policía Local 3, 46015 Valencia, Spain

Correspondence should be addressed to Elena Labarta; se.ivi@atrabal.anele

Received 13 November 2016; Accepted 23 February 2017; Published 27 March 2017

Academic Editor: Mittal Suneeta

Copyright © 2017 Elena Labarta et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

This study has analysed the relationship between ovarian response and the number of euploid embryos. This is a post hoc analysis of a subset of data generated during a prospective cohort study previously published. Forty-six oocyte donors were subjected to ovarian stimulation with 150 IU of rFSH and 75 IU of hp-hMG in a GnRH agonist long protocol. Preimplantation genetic screening was performed in all viable embryos. We observed a positive relationship between ovarian response and the number of euploid embryos. When ovarian response was above the median (≥17 oocytes), the mean number of euploid embryos per donor was 5.0 ± 2.4, while when <17 oocytes were obtained the mean number of euploid embryos was 2.7 ± 1.4 (). Aneuploidy rate did not increase with ovarian response or gonadotropin doses. Also, the number of euploid embryos was inversely related to the amount of gonadotropins needed per oocyte obtained (ovarian sensitivity index). These results suggest that the number of euploid embryos available for embryo transfer increases as the number of oocytes obtained does. Considering the total number of euploid embryos seems more relevant than the aneuploidy rate.