XRRA1 Targets ATM/CHK1/2-Mediated DNA Repair in Colorectal Cancer

Figure 4

Ionizing radiation downregulated the expression of XRRA1 at mRNA and protein levels in CRC cells. (a) Cells were treated with different irradiation doses for 24 h and assessed for relative mRNA expression of XRRA1 using quantitative real-time PCR. Error bars indicate standard deviations of three independent experiments. (b) The cells were treated with 6 Gy at different times and assessed for the relative mRNA expression of XRRA1 using quantitative real-time PCR. The average expression of the target gene was normalized to the corresponding value for GAPDH and expressed as the fold change compared with controls.

(a)

(b)