XRRA1 Targets ATM/CHK1/2-Mediated DNA Repair in Colorectal Cancer

<div><i>Downregulated expression of XRRA1 in CRC cells regulates ATM/CHK1/2 pathway to mediated DNA damage response after ionizing radiation</i>. (a) Western blot analyses of pCHK1, pCHK2, and r-H2AX in HT29 and HCT116 cells were irradiated for 6 hours. (b) Immunofluorescence staining of <i>γ</i>-H2AX to evaluate the expression of sh-XRRA1 in HT29 and HCT116 cells was irradiated for 6 hours.</div>

BioMed Research International

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Figure 5

Figure 5: XRRA1 Targets ATM/CHK1/2-Mediated DNA Repair in Colorectal Cancer 