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BioMed Research International
Volume 2017, Article ID 5783719, 6 pages
Research Article

CYP2C192 Polymorphism in Chilean Patients with In-Stent Restenosis Development and Controls

1Center of Molecular Biology and Pharmacogenetics, Scientific and Technological Bioresource Nucleus, Universidad de La Frontera, Temuco, Chile
2Department of Internal Medicine, Faculty of Medicine, Universidad de La Frontera, Temuco, Chile
3Facultad de Medicina, Universidad de Concepción, Concepción, Chile

Correspondence should be addressed to Luis A. Salazar; lc.aretnorfu@razalas.siul

Received 1 March 2017; Accepted 6 June 2017; Published 13 July 2017

Academic Editor: Stelvio M. Bandiera

Copyright © 2017 Jenny Ruedlinger et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Clopidogrel is an antiplatelet drug especially used in patients undergoing percutaneous coronary interventions (PCI). Polymorphisms within CYP2C19 can result in important interindividual variations regarding therapeutic efficacy. Therefore, we aimed to evaluate the impact of the CYP2C192 variant (rs4244285) on in-stent restenosis occurrence in Chilean patients who underwent PCI and received clopidogrel. A total of 77 cases with stenosis >50% in the angioplasty site (62.75 ± 9.8 years, 80.5% males) and 86 controls (65.45 ± 9.8 years, 72.1% males) were studied. The polymorphism was genotyped using TaqMan® Drug Metabolism Genotyping Assays. Overall, CYP2C192 allele frequency was 8.3%. Diabetes, chronic lesions, and bare metal stents (BMS) were observed more often in cases than in controls (p = 0.05, p = 0.04, and p = 0.02, resp.). Genotypic frequencies did not differ significantly between the groups (p = 0.15). Nonetheless, the mutated allele was observed in a greater proportion in patients without in-stent restenosis (p = 0.055). There was no significant association between the rs4244285 variant and the occurrence of in-stent restenosis after PCI (OR = 0.44; 95% CI: 0.19 to 1.04; p = 0.06). In summary, no association was identified between the CYP2C192 variant and the development of coronary in-stent restenosis.