Antimicrobial Activity of Quinazolin Derivatives of 1,2-Di(quinazolin-4-yl)diselane against Mycobacteria

Figure 6

ROS levels and iron concentration during DQYD treatment. M. tuberculosis H37Ra cells treated with different concentrations of DQYD (0-40 μg/mL) for 14 days (a) and then stained with dihydroethidium for ROS detection. The ROS levels were measured by flow cytometry and the data was analyzed using FlowJo. Total iron bound and ferrous and ferric iron concentrations in M. tuberculosis H37Ra treated with DQYD for 14 days were measured as described in Material and Methods (b).

(a)

(b)