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BioMed Research International
Volume 2017, Article ID 5796456, 6 pages
Research Article

Effect of a Carbohydrate-Rich Diet on Rat Detrusor Smooth Muscle Contractility: An Experimental Study

1Department of Urology, Samsun Training and Research Hospital, Health Sciences University, Samsun, Turkey
2Department of Pharmacology, Ondokuz Mayıs University, Samsun, Turkey
3Urology Clinic, Tokat State Hospital, Tokat, Turkey
4Department of Pathology, Samsun Training and Research Hospital, Health Sciences University, Samsun, Turkey
5Department of Pathology, Medical Faculty, Gaziosmanpaşa University, Tokat, Turkey
6Department of Urology, Gaziosmanpaşa University, Tokat, Turkey

Correspondence should be addressed to Mustafa Suat Bolat; moc.liamg@talobsm

Received 11 March 2017; Revised 20 July 2017; Accepted 30 August 2017; Published 19 October 2017

Academic Editor: Anna Malykhina

Copyright © 2017 Mustafa Suat Bolat et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Objectives. We aimed to investigate the effect of a carbohydrate-rich diet on detrusor contractility in rats. Materials and Methods. Sprague-Dawley rats were randomized into two groups. The control group received regular food and water. The study group received carbohydrate-rich diet for six weeks. The rats’ detrusor muscle was isolated for pharmacological and histopathological examinations. Results. In the control and study groups, mean body weights were 431.5 ± 27.6 g and 528.0 ± 36.2 g, respectively (p < 0.001). Electrical stimulation of the detrusor strips of the control group resulted in gradual contraction. A decreased contractile response was shown in the study group. Acetylcholine in 10-7-10-3 molar concentration produced a decreased contractile response in the study group, compared to the control group (p < 0.01). The study group showed marked subepithelial and intermuscular fibrosis in the bladder. Conclusion. Carbohydrate-rich diet causes marked subepithelial and extracellular fibrosis and changes in contractility in the detrusor within a six-week period. Changes have higher costs in therapeutic choices and correction of these changes remains difficult. Putting an end to carbohydrate-rich diet would seem to be more cost-effective than dealing with the effects of consuming it in high proportions which should be the national policy worldwide.