Effects of Fungicides on Rat’s Neurosteroid Synthetic Enzymes

Figure 1

Kinetics of SRD5A1 and the inhibition of fungicides. Panel (a): kinetics of SRD5A1 with testosterone (T) as the substrate. Panel (b): % inhibition by tebuconazole (TEB), triadimefon (TRI), and vinclozolin (VCZ) at 100 µM. Panels (c) and (d): IC₅₀ values of TEB and TRI. Mean ± SEM; indicates a significant difference compared to the control (CON) at .

(a) 5α-Red1

(b) 5α-Red1

(c) 5α-Red1:TEB

(d) 5α-Red1:TRI