Table of Contents Author Guidelines Submit a Manuscript
BioMed Research International
Volume 2017, Article ID 5829756, 8 pages
https://doi.org/10.1155/2017/5829756
Research Article

Effects of Fungicides on Rat’s Neurosteroid Synthetic Enzymes

1Department of Pharmacy, The Third Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang 325200, China
2Department of Anesthesiology, The Second Affiliated Hospital and Yuying Children’s Hospital of Wenzhou Medical University, Wenzhou, Zhejiang 325027, China
3Department of Pharmacy, Zhejiang Cancer Hospital, Hangzhou, Zhejiang 310022, China

Correspondence should be addressed to Ren-Shan Ge; moc.oohay@eg_r

Received 16 March 2017; Revised 21 May 2017; Accepted 4 June 2017; Published 24 July 2017

Academic Editor: Jane Hanrahan

Copyright © 2017 Xiuwei Shen et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. X. You, Y. Li, X. Wang et al., “Residue analysis and risk assessment of tebuconazole in jujube (Ziziphus jujuba Mill),” Biomedical Chromatography, vol. 31, no. 7, p. e3917, 2017. View at Publisher · View at Google Scholar
  2. Y. Liu, D. Shen, S. Li et al., “Residue levels and risk assessment of pesticides in nuts of China,” Chemosphere, vol. 144, pp. 645–651, 2016. View at Publisher · View at Google Scholar · View at Scopus
  3. M. M. Frias, M. J. Torres, A. G. Frenich, J. L. M. Vidal, F. Olea-Serrano, and N. Olea, “Determination of organochlorine compounds in human biological samples by GC-MS/MS,” Biomedical Chromatography, vol. 18, no. 2, pp. 102–111, 2004. View at Publisher · View at Google Scholar · View at Scopus
  4. L. Li, Y. Wang, X. Li et al., “Regulation of development of rat stem and progenitor leydig cells by activin,” Andrology, vol. 5, no. 1, pp. 125–132, 2017. View at Publisher · View at Google Scholar
  5. K. J. Turner, M. Morley, N. Atanassova, I. D. Swanston, and R. M. Sharpe, “Effect of chronic administration of an aromatase inhibitor to adult male rats on pituitary and testicular function and fertility,” Journal of Endocrinology, vol. 164, no. 2, pp. 225–238, 2000. View at Publisher · View at Google Scholar · View at Scopus
  6. J. A. Zarn, B. J. Brüschweiler, and J. R. Schlatter, “Azole fungicides affect mammalian steroidogenesis by inhibiting sterol 14α-demethylase and aromatase,” Environmental Health Perspectives, vol. 111, no. 3, pp. 255–261, 2003. View at Publisher · View at Google Scholar · View at Scopus
  7. D. Belelli and J. J. Lambert, “Neurosteroids: endogenous regulators of the GABAA receptor,” Nature Reviews Neuroscience, vol. 6, no. 7, pp. 565–575, 2005. View at Publisher · View at Google Scholar · View at Scopus
  8. D. S. Reddy, “Mass spectrometric assay and physiological-pharmacological activity of androgenic neurosteroids,” Neurochemistry International, vol. 52, no. 4-5, pp. 541–553, 2008. View at Publisher · View at Google Scholar · View at Scopus
  9. D. M. Berman and D. W. Russell, “Cell-type-specific expression of rat steroid 5 alpha-reductase isozymes,” Proceedings of the National Academy of Sciences, vol. 90, no. 20, pp. 9359–9363, 1993. View at Publisher · View at Google Scholar
  10. H. J. Karavolas and D. R. Hodges, “Neuroendocrine Metabolism of Progesterone and Related Progestins,” in Ciba Foundation Symposium 153 - Steroids and Neuronal Activity, Novartis Foundation Symposia, pp. 22–55, John Wiley & Sons, Ltd., Chichester, UK, 2007. View at Publisher · View at Google Scholar
  11. N. R. Krieger and R. G. Scott, “3α-Hydroxysteroid Oxidoreductase in Rat Brain,” Journal of Neurochemistry, vol. 42, no. 3, pp. 887–890, 1984. View at Publisher · View at Google Scholar · View at Scopus
  12. X. Chai, Y. Zhai, and J. L. Napoli, “Cloning of a rat cDNA encoding retinol dehydrogenase isozyme type III,” Gene, vol. 169, no. 2, pp. 219–222, 1996. View at Publisher · View at Google Scholar · View at Scopus
  13. D. O. Hardy, R.-S. Ge, J. F. Catterall, Y.-T. Hou, T. M. Penning, and M. P. Hardy, “Identification of the oxidative 3α-hydroxysteroid dehydrogenase activity of rat Leydig cells as type II retinol dehydrogenase,” Endocrinology, vol. 141, no. 5, pp. 1608–1617, 2000. View at Publisher · View at Google Scholar · View at Scopus
  14. R.-S. Ge, H.-B. Gao, V. L. Nacharaju, G. L. Gunsalus, and M. P. Hardy, “Identification of a kinetically distinct activity of 11beta-hydroxysteroid dehydrogenase in rat leydig cells,” Endocrinology, vol. 138, no. 6, pp. 2435–2442, 1997. View at Publisher · View at Google Scholar · View at Scopus
  15. M. J. Bennett, R. H. Albert, J. M. Jez, H. Ma, T. M. Penning, and M. Lewis, “Steroid recognition and regulation of hormone action: Crystal structure of testosterone and NADP+ bound to 3α-hydroxysteroid/dihydrodiol dehydrogenase,” Structure, vol. 5, no. 6, pp. 799–812, 1997. View at Publisher · View at Google Scholar · View at Scopus
  16. A. Grosdidier, V. Zoete, and O. Michielin, “SwissDock, a protein-small molecule docking web service based on EADock DSS,” Nucleic Acids Research, vol. 39, no. 2, pp. W270–W277, 2011. View at Publisher · View at Google Scholar · View at Scopus
  17. E. Dong, K. Matsumoto, V. Uzunova et al., “Brain 5α-dihydroprogesterone and allopregnanolone synthesis in a mouse model of protracted social isolation,” Proceedings of the National Academy of Sciences of the United States of America, vol. 98, no. 5, pp. 2849–2854, 2001. View at Publisher · View at Google Scholar · View at Scopus
  18. D. A. Finn, A. S. Beadles-Bohling, E. H. Beckley et al., “A new look at the 5α-reductase inhibitor finasteride,” CNS Drug Reviews, vol. 12, no. 1, pp. 53–76, 2006. View at Publisher · View at Google Scholar · View at Scopus
  19. R. C. Agis-Balboa, G. Pinna, A. Zhubi et al., “Characterization of brain neurons that express enzymes mediating neurosteroid biosynthesis,” Proceedings of the National Academy of Sciences of the United States of America, vol. 103, no. 39, pp. 14602–14607, 2006. View at Publisher · View at Google Scholar · View at Scopus
  20. R. C. Agis-Balboa, G. Pinna, F. Pibiri, B. Kadriu, E. Costa, and A. Guidotti, “Down-regulation of neurosteroid biosynthesis in corticolimbic circuits mediates social isolation-induced behavior in mice,” Proceedings of the National Academy of Sciences of the United States of America, vol. 104, no. 47, pp. 18736–18741, 2007. View at Publisher · View at Google Scholar · View at Scopus
  21. J. Xi, Z. Yang, C. Zeng, X. Hu, and J. Wang, “Suppressive effect of triadimefon, a triazole fungicide, on spatial learning and reference memory in rats,” Behavioural Pharmacology, vol. 23, no. 8, pp. 727–734, 2012. View at Publisher · View at Google Scholar · View at Scopus
  22. V. C. Moser, S. Barone Jr., R. J. Smialowicz et al., “The effects of perinatal tebuconazole exposure on adult neurological, immunological, and reproductive function in rats,” Toxicological Sciences, vol. 62, no. 2, pp. 339–352, 2001. View at Publisher · View at Google Scholar · View at Scopus
  23. F. Gagnaire and J.-C. Micillino, “Effects of triadimefon on extracellular dopamine, DOPAC, HVA and 5-HIAA in adult rat striatum,” Toxicology, vol. 217, no. 2-3, pp. 91–104, 2006. View at Publisher · View at Google Scholar · View at Scopus
  24. M. Golshan, A. Hatef, A. Zare et al., “Alternations in neuroendocrine and endocrine regulation of reproduction in male goldfish (Carassius auratus) following an acute and chronic exposure to vinclozolin, in vivo,” Aquatic Toxicology, vol. 155, pp. 73–83, 2014. View at Publisher · View at Google Scholar · View at Scopus