HIF1A (rs11549465) and AKNA (rs10817595) Gene Polymorphisms Are Associated with Primary Sjögren’s Syndrome
Table 3
Odds ratio for primary Sjögren’s syndrome by polymorphisms genotypes, alleles, and inheritance models.
Polymorphism
(controls/cases)
OR (95% CI)
value
HIF1A Pro582Ser (rs11549465)
C/C
94/94
1.00
C/T
41/12
0.22 (0.09–0.52)
<0.01
T/T
0/0
—
—
Alleles
C
229/200
1.00
T
41/12
0.26 (0.12–0.58)
<0.01
HIF1A C191T (rs2057482)
T/T
96/94
1.00
T/C
23/16
0.43 (0.18–1.04)
0.06
C/C
0/0
—
—
Alleles
T
215/204
1.00
C
23/16
0.47 (0.21–1.07)
0.07
AKNA −1372 C>A (rs10817595)
C/C
41/31
1.00
C/A
84/53
0.64 (0.31–1.32)
0.23
A/A
16/22
1.94 (0.73–5.15)
0.19
Inheritance models
C/A + A/A
100/75
0.82 (0.41–1.64)
0.58
A/A
16/22
2.60 (1.11–6.12)
0.03
Alleles
C
166/115
1.00
A
116/97
1.20 (0.78–1.86)
0.42
AKNA Pro624Leu (rs3748176)
G/G
39/30
1.00
G/A
78/54
0.76 (0.37–1.58)
0.46
A/A
22/22
1.56 (0.62–3.96)
0.35
Inheritance models
G/A + A/A
100/76
0.92 (0.46–1.83)
0.80
A/A
22/22
1.88 (0.85–4.16)
0.12
Alleles
G
156/114
1.00
A
122/98
1.17 (0.75–1.81)
0.48
Odds ratio adjusted by age and gender. Recessive inheritance model; the reference group is formed by C/A and C/C genotype carriers or G/A and G/G genotype carriers for each AKNA polymorphism, respectively. Odds ratio statistically significant after bootstrap resampling (100 repetitions).
