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BioMed Research International
Volume 2017, Article ID 5846073, 7 pages
Research Article

Electrostatic Switch Function in the Mechanism of Protein Kinase A I Activation: Results of the Molecular Dynamics Simulation

1St. Petersburg State University, Universitetskaya nab. 7/9, St. Petersburg 199034, Russia
2Pavlov Institute of Physiology, Russian Academy of Sciences, nab. Makarova 6, St. Petersburg 199034, Russia
3Kyoto Sangyo University, Kamigamo-Motoyama, Kita-ku, Kyoto 603-8555, Japan

Correspondence should be addressed to Alexander A. Tokmakov; and Vasiliy E. Stefanov; ur.liam@fetsav

Received 6 November 2016; Revised 22 January 2017; Accepted 7 February 2017; Published 7 March 2017

Academic Editor: Serdar Kuyucak

Copyright © 2017 Olga N. Rogacheva et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Supplementary Material

Supplementary material comprises two files. The PDF contains definition of collective variables and specification of thirteen productive trajectories. The Movie file represents animated sequence of transition events shown in Figures 1-4.

  1. Supplementary Material