Rapid Elimination of Blood Alcohol Using Erythrocytes: Mathematical Modeling and In Vitro Study

Figure 1

Schematic representation of metabolic pathways of the enzymes encapsulated into RBC for the ethanol detoxification. Alcohol dehydrogenase (ADH) catalyzes an ethanol oxidation to acetaldehyde. After that, aldehyde dehydrogenase (ALD) metabolizes acetaldehyde to acetate. Both reactions involve the NAD⁺ reduction. These enzymes employ glycolysis for their function, since they use lactate dehydrogenase (LDH) of RBC for oxidation of generated NADH to NAD⁺.