Anti-Gouty Arthritis and Antihyperuricemia Effects of Sunflower (Helianthus annuus) Head Extract in Gouty and Hyperuricemia Animal Models
Table 3
The effects of AL and SHEB on oxidative status in serum, kidney, and liver of hyperuricemia mice.
NC
MC
AL (20 mg/kg)
SHEB (1 g/kg)
Serum
GSH-Px (U/mL)
225.9 ± 26.9
218.4 ± 23.9
226.8 ± 33.6
215.0 ± 18.1
SOD (U/mL)
124.8 ± 17.2
111.9 ± 16.2
110.3 ± 15.5
110.4 ± 16.9
MDA (nmol/mL)
8.5 ± 0.8
7.9 ± 0.9
7.6 ± 1.1
7.9 ± 0.8
NO (μmol/mL)
18.1 ± 2.2
19.1 ± 1.5
18.1 ± 2.5
17.8 ± 1.2
Kidney
GSH-Px (U/g)
19541.1 ± 2253.8
20792.8 ± 4724.7
20603.9 ± 5344.4
19508.8 ± 1927.6
SOD (U/g)
11568.6 ± 1392.6
9064.7 ± 1953.8
10605.9 ± 1685.8
8242.3 ± 1082.7
MDA (nmol/g)
977.1 ± 51.7
880.5 ± 263.9
651.7 ± 129.4
633.0 ± 58.1
NO (μmol/g)
2181.8 ± 277.5
2211.9 ± 708.9
1847.1 ± 305.4
1726.9 ± 308.8
Liver
GSH-Px (U/g)
16049.4 ± 3777.3
24365.6 ± 8867.3
12887.8 ± 4900.8
8470.9 ± 2640.0
SOD (U/g)
6852.8 ± 782.8
9090.2 ± 2456.2
5773.1 ± 753.7
3707.1 ± 538.6
MDA (nmol/g)
557.9 ± 91.4
1062.4 ± 215.4
503.7 ± 73.2
356.7 ± 64.6
NO (μmol/g)
1409.9 ± 180.3
2018.2 ± 418.0
1120.6 ± 234.6
826.8 ± 99.2
Data are expressed as mean ± SD and analyzed using a one-way ANOVA followed by post hoc Dunn’s multiple comparisons test. and versus control mice, , , and versus model mice. NC: normal control, MC: model control, COL: colchicine, SHEB: sunflower head extract B, GSH-Px: glutathione peroxidase, SOD: superoxide dismutase, MDA: malondialdehyde, and NO: nitrogen monoxide (NO).
