Renoprotective Effects of Aldose Reductase Inhibitor Epalrestat against High Glucose-Induced Cellular Injury

Figure 5

Effects of epalrestat on high glucose-induced renal cell injury and cell cycle progression. (a) Cell viability of NRK-52E cells after exposure to high glucose with and without 1 µM epalrestat for 48 h as determined by MTT assay. Values were expressed as percentage Mean ± SEM relative to vehicle-treated control. compared to control. (b) Distribution of NRK-52E cells along cell cycle after incubation with high glucose and mannitol in the presence or absence of epalrestat (1 M). Summarized data were reported in Table 1.

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