Monoclonal Antibodies Radiolabeling with Rhenium-188 for Radioimmunotherapy
Table 2
Pros and cons between direct and indirect labeling methods.
Labeling methods
Pros
Cons
Direct
(i) Simpler approach (ii) Less complicated antibody preparation (iii) Fewer reaction steps (iv) Reactions frequently conducted at room temperature (v) Rapid procedure (vi) More appropriate for freeze-dried kit formulation
(i) Site unspecific (ii) Less stable radioimmunoconjugates
Indirect
(i) Site specific (ii) More stable radioimmunoconjugates
(i) More complicated approach (ii) More complicated antibody preparation (iii) More reaction steps (iv) Reactions frequently conducted at high temperature (v) Slow procedure (vi) Postradiolabeling purification