Circular RNA Profiling and Bioinformatic Modeling Identify Its Regulatory Role in Hepatic Steatosis

Figure 3

Target prediction of steatosis-related circRNAs. (a–f) Complementary binding of the top-six differentially expressed circRNAs and target miRNAs. The 2D structures show the complementation between circRNAs and miRNAs at both seed and 3′ pairing sequences (nucleotides 13–16). AU content 30 nt upstream and downstream of the seed sequence, respectively, is shown in the column of Local AU. Black bars reflect G/C and low accessibility, whereas red bars reflect A/U and high accessibility of seed sequence. Height of these bars shows the degree of accessibility. The column of position shows the location of microRNA response elements (MREs) in circRNAs.

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