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BioMed Research International
Volume 2017, Article ID 5965492, 8 pages
Research Article

The Role of Intereukin-31 in Pathogenesis of Itch and Its Intensity in a Course of Bullous Pemphigoid and Dermatitis Herpetiformis

Department of Dermatology and Venereology, Medical University of Lodz, Poland Hallera Square No. 1, 90-647 Lodz, Poland

Correspondence should be addressed to Lilianna Kulczycka-Siennicka;

Received 2 April 2017; Revised 25 May 2017; Accepted 12 June 2017; Published 20 July 2017

Academic Editor: Adam Reich

Copyright © 2017 Lilianna Kulczycka-Siennicka et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Itch which is one of the major, subjective symptoms in a course of bullous pemphigoid and dermatitis herpetiformis makes those two diseases totally different than other autoimmune blistering diseases. Its pathogenesis is still not fully known. The aim of this research was to assess the role of IL-31 in development of itch as well as to measure its intensity. Obtained results, as well as literature data, show that lower concentration of IL-31 in patients’ serum may be correlated with its role in JAK/STAT signaling pathway which is involved in development of autoimmune blistering disease. Intensity of itch is surprisingly huge problem for the patients and the obtained results are comparable with results presented by atopic patients.