Systematic Approach for the Formulation and Optimization of Solid Lipid Nanoparticles of Efavirenz by High Pressure Homogenization Using Design of Experiments for Brain Targeting and Enhanced Bioavailability

Table 3

Comparison of formulation techniques on the basis of particle size, PDI, and entrapment efficiency are expressed as mean ± SD (); # indicates statistical significance (). PDI: polydispersity .

S. number	Batch; number	Technique	Particle; (nm)		Entrapment; (%)
1	SFT01	Solvent; evaporation
2	SFT02	High pressure; homogenization	376.3 ± 9.5^#	0.380 ± 0.101	64.76 ± 1.9^#