Systematic Approach for the Formulation and Optimization of Solid Lipid Nanoparticles of Efavirenz by High Pressure Homogenization Using Design of Experiments for Brain Targeting and Enhanced Bioavailability

Table 4

Full factorial design with coded and actual values used for optimization of process variables. (independent variable: pressure and number of cycles; dependent variable: particle size and polydispersity index—PDI).

S. number	Batch; number	Coded values		Actual values		Particle size; (nm)	PDI
		Pressure; (bar)	Number of cycles	Pressure; (bar)	Number of cycles
1	OPC01			500	3	501.0	0.469
2	OPC02			700	3	403.1	0.440
3	OPC03			900	3	309.8	0.412
4	OPC04			500	5	457.7	0.386
5	OPC05			700	5	376.3	0.380
6	OPC06			900	5	246.1	0.259
7	OPC07			500	7	379.9	0.326
8	OPC08			700	7	352.7	0.359
9	OPC09			900	7	235.6	0.261
10	OPC10			700	5	390.2	0.253
11	OPC11			700	5	405.5	0.301
12	OPC12			700	5	389.9	0.286
13	OPC13			700	5	399.3	0.298