Systematic Approach for the Formulation and Optimization of Solid Lipid Nanoparticles of Efavirenz by High Pressure Homogenization Using Design of Experiments for Brain Targeting and Enhanced Bioavailability

Full factorial design with coded and actual values used for optimization of formulation variables (independent variable: amount of drug with respect to lipid and concentration of surfactant; dependent variable: particle size, polydispersity index (PDI), and entrapment efficiency (EE)).

BioMed Research International

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Table 6

Table 6: Systematic Approach for the Formulation and Optimization of Solid Lipid Nanoparticles of Efavirenz by High Pressure Homogenization Using Design of Experiments for Brain Targeting and Enhanced Bioavailability 

Table 6 | Systematic Approach for the Formulation and Optimization of Solid Lipid Nanoparticles of Efavirenz by High Pressure Homogenization Using Design of Experiments for Brain Targeting and Enhanced Bioavailability 