Clinicopathological and Prognostic Role of Long Noncoding RNA Linc00152 in Various Human Neoplasms: Evidence from Meta-Analysis

Table 2

HRs and 95% CIs of cancer prognosis and progression associated with linc00152 expression in included studies.

Study

Year

Tumor type

Main assay method

Cut-off value

Case number of linc00152 expression

OS

value

DFS/PFS

value

High

High with LNM

High with DM

High with VI

Low

Low with LNM

Low with DM

Low with VI

HR (95% CI) (U/M)

HR (95% CI) (U/M)

Chen et al.

2017

Lung adenocarcinoma

qRT-PCR

Median

30

25

NR

NR

30

13

NR

NR

2.31 (0.66–8.04) U

0.005

3.43 (1.10–10.69) U

<0.001

Wu et al.

2016

ccRCC

qRT-PCR

Mean

38

NR

8

4

39

NR

12

11

2.577 (1.233–5.387) M

0.012

NR

NR

Hu et al.

2016

ESCC

qRT-PCR

NR

131

NR

NR

NR

74

NR

NR

NR

1.888 (1.220–2.581) M

0.0028

NR

NR

Cai et al.

2016

Gallbladder cancer

qRT-PCR

Median

23

15

NR

6

17

5

NR

3

NR

NR

NR

NR

Cai et al.

2016

Gallbladder cancer

qRT-PCR

Median

18

12

NR

NR

17

5

NR

NR

2.14 (0.53–8.57) U

<0.05

NR

NR

Yue et al.

2016

Colon cancer

qRT-PCR

Median

98

50

NR

7

38

18

NR

1

3.67 (1.64–8.21) M

0.002

3.56 (1.59–7.97) M

0.002

Chen et al.

2016

Gastric cancer

qRT-PCR

Median

49

43

NR

NR

48

34

NR

NR

1.659 (1.008–2.731) M

0.047

NR

NR

Ji et al.

2015

HCC

qRT-PCR

Median

51

NR

NR

9

51

NR

NR

6

NR

NR

NR

NR

The source of HR and 95% CI was extracted from survival curves or article reports. HR calculated from survival curves; SC, survival curve; U, univariate analysis; M, multivariate analysis; NR, not reported. ccRCC, clear cell renal cell carcinoma; ESCC, esophageal squamous cell carcinoma; HCC, hepatocellular carcinoma. LNM, lymph node metastasis; DM, distant metastasis; VI, vessel invasion; OS, overall survival; DFS, disease-free survival; PFS, progression-free survival. qRT-qPCR, reverse transcriptase-quantitative PCR.