Review Article
Long Noncoding RNAs Act as Novel Biomarkers for Hepatocellular Carcinoma: Progress and Prospects
Table 2
Dysregulated lncRNAs in serum of HCC patients.
| Name | Dysregulation | Samples (HCC/Control) | Description | Area under the ROC curve | Reference |
| HULC | Up | 30/20 | Increase with Edmondson grade, detected more frequently in HBV+ HCC patients | Not reported | [35] | Up | 90/77 | Correlated with tumor size and tumor capsule | 0.78 | [36] |
| Linc00152 | Up | 90/77 | Related to differentiation grade, tumor size, TNM stage and tumor capsule | 0.85 | [36] |
| MALAT1 | Up | 88/79 | Significantly lower in HCC patients with hepatitis B infection and significantly higher in patients with liver damage B or liver cirrhosis | 0.66 | [41] |
| HEIH | Up | 179/179 | Positively related to TNM stage and the risk of HCC | 0.681 | [39] |
| PVT1 | Up | 71/64 | Associated with clinical parameters including tumor size, BCLC stage and serum bilirubin | 0.764 (combined with uc002mbe.2) | [43] |
| uc002mbe.2 | Up | 71/64 | Same with PVT1 | 0.764 (combined with PVT1) | [43] |
| UCA1 | Up | 82/78 | Associated with HCV-antibodies positive patients and Child-Pugh score | 0.861 | [40] |
| WRAP53 | Up | 82/78 | Same with UCA1 | 0.896 | [40] |
| uc003wbd | Up | 137/138 | Also significantly highly expressed in HBV patients | 0.86 | [37] |
| AF085935 | Up | 137/138 | Same with uc003wbd | 0.96 | [37] |
| uc001ncr | Up | 232/452 | High diagnostic performance in patients with AFP <400 ng/ml and early HCC | 0.8859 | [42] |
| AX800134 | Up | 232/452 | Same with uc001ncr | 0.9251 | [42] |
| RP11-160H22.5 | Up | 217/250 | Decrease after operation | 0.601 | [38] |
| XLOC_014172 | Up | 217/250 | Higher expression in HCC patients with metastasis | 0.866 | [38] |
| LOC149086 | Up | 217/250 | Same with XLOC_014172 | 0.759 | [38] |
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