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BioMed Research International
Volume 2017, Article ID 6073167, 8 pages
Review Article

Do miRNAs Play a Role in Fetal Growth Restriction? A Fresh Look to a Busy Corner

1Unit of Gynecology and Obstetrics, Department of Human Pathology in Adulthood and Childhood “G. Barresi”, University of Messina, Messina, Italy
2Unit of Psychodiagnostics and Clinical Psychology, University of Catania, Catania, Italy
3Department of Maternal and Child Health, Gavardo Hospital, Brescia, Italy
4Department of General Surgery and Medical Surgical Specialties, University of Catania, Catania, Italy

Correspondence should be addressed to Antonio Simone Laganà; ti.eminu@anagaltna

Received 31 January 2017; Accepted 20 March 2017; Published 29 March 2017

Academic Editor: Erich Cosmi

Copyright © 2017 Benito Chiofalo et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Placenta is the crucial organ for embryo and fetus development and plays a critical role in the development of fetal growth restriction (FGR). There are increasing evidences on the role of microRNAs (miRNAs) in a variety of pregnancy-related complications such as preeclampsia and FGR. More than 1880 miRNAs have been reported in humans and most of them are expressed in placenta. In this paper, we aimed to review the current evidence about the topic. According to retrieved data, controversial results about placental expression of miRNAs could be due (at least in part) to the different experimental methods used by different groups. Despite the fact that several authors have demonstrated a relatively easy and feasible detection of some miRNAs in maternal whole peripheral blood, costs of these tests should be reduced in order to increase cohorts and have stronger evidence. In this regard, we take the opportunity to solicit future studies on large cohort and adequate statistical power, in order to identify a panel of biomarkers on maternal peripheral blood for early diagnosis of FGR.