| | Authors, year | Type of study | Enrolled population | Methods of analysis | Samples | Main findings |
| | Cindrova-Davies et al., 2013 [8] | Case-control | 6 FGR, 6 PE-AD, 7 PE-ND, 7 HP (controls) | RT-qPCR | Placentas | Expression of miR-21 was significantly upregulated in PE-AD and FGR cases, but not in PE-ND cases |
| | Guo et al., 2013 [9] | Case-control | 26 FGR, 16 PE, 29 HP (controls) | RT-qPCR | Placentas | Downregulation of miR-149 was shown in PE cases; miR-194 was significantly downregulated in FGR and PE cases |
| | Hromadnikova et al., 2015 [10] | Case-control | 35 GH, 80 PE, 35 FGR, 20 HP (controls) | RT-qPCR | Placentas | (i) Upregulation of miR-499a-5p in PE, GH, FGR cases;
(ii) upregulation of miR-1-3p FGR-AD in PE cases delivering after 34 weeks;
(iii) downregulation of miR-26a-5p, miR-103a-3p, miR-145-5p in PE and FGR cases requiring delivery before 34 weeks;
(iv) downregulation of miR-16-5p, miR-100-5p, miR-122-5p, miR-125b-5p, miR-126-3p, miR-143-3p, miR-195-5p, miR-199a-5p, miR-221-3p, miR-342-3p, miR-574-3p in FGR cases requiring delivery before 34 weeks |
| | Huang et al., 2013 [11] | Case-control | 25 FGR, 25 HP (controls) | RT-qPCR | Placentas | Upregulation of miR-424 |
| | Tang et al., 2013 [13] | Case-control | 21 FGR, 34 HP (controls) | RT-qPCR | Placentas | High expression level of miR-141 in FGR cases |
| | Donker et al., 2012 [14] | Case-control | 14 FGR, 14 HP (controls) | RT-qPCR | Placentas | Hypoxic stress does not affect C19MC miRNA expression, except for downregulation of miR-500c-3p |
| | Higasijima et al., 2013 [15] | Two-step case-control | First step: 45 FGR, 50 HP (controls) | RT-qPCR | Placentas | (i) miR-518b, miR-1323, miR-516b, miR-515-5p, miR-520h, miR-519d, miR-526b were significantly lower in FGR placentas than in controls;
(ii) no differences in miR-516a-5p, miR-525-5p, miR-520a-5p levels | | Second step: 10 FGR, 10 HP (controls) | RT-qPCR | Maternal plasma/serum | No differences were found in miR-518b, hsa-miR-1323, hsa-miR-520h, hsa-miR-519d levels between FGR cases and controls |
| | Wang et al., 2014 [16] | Case-control | 30 FGR, 30 LGA, 30 NGA (controls) | RT-qPCR | Placentas | Decreased expression of miR-518b and increased expression of miR-519a in FGR cases with respect to NGA and LGA cases |
| | Hromadnikova et al., 2015 [17] | Case-control | 21 GH, 63 PE, 36 FGR, 42 HP (controls) | RT-qPCR | Placentas | (i) Downregulation of miR-517-5p, miR-519d, miR-520a-5p, miR-525 in GH cases;
(ii) downregulation of miR-517-5p, miR-518f-5p, miR-519a, miR-519d, miR-520a-5p, miR-525 in FGR cases;
(iii) downregulation of miR-515-5p, miR-517-5p, miR-518b, miR-518f-5p, miR-519a, miR-519d, miR-520a-5p, miR-520h, miR-524-5p, miR-525, miR-526a in PE cases |
| | Hromadnikova et al., 2012 [44] | Case-control | 16 PE, 11 FGR, 5 PE and FGR, 7 normal pregnancies with later onset of PE and/or FGR, 10 NP (controls), 50 HP (controls) | RT-qPCR | Maternal plasma/serum | (i) No differences were found in miR-516-5p, miR-517, miR-518b, miR-520a, miR-520h, miR-525, miR-526a concentrations between pathologic and normal pregnancies;
(ii) significant elevation of miR-516-5p, miR-517, miR-518b, miR-520a, miR-520h, miR-525, miR-526a levels during early gestation in pregnancies with later onset of PE and/or FGR |
| | Hromadnikova et al., 2013 [45] | Case-control | 63 PE, 27 FGR, 23 GH, 55 HP (controls) | RT-qPCR | Maternal plasma/serum | (i) Plasmatic levels of miR-516-5p, miR-517, miR-520a, miR-525, miR-526a did not differ between FGR, GH, and HP patients;
(ii) increased plasmatic levels and high expression of miR-516-5p, miR-517, miR-520a, miR-525, miR-526a were found in PE patients |
| | Hromadnikova et al., 2016 [46] | Case-control | 39 GH, 68 PE, 33 FGR, 20 HP (controls) | RT-qPCR | Maternal plasma/serum | (i) Downregulation of miR-100-5p, miR-125b-5p, miR-199a-5p in GH, PE, FGR cases compared with controls;
(ii) downregulation of miR-17-5p, miR-146a-5p, miR-221-3p, miR-574-3p in FGR cases;
(iii) downregulation of miR-100-5p, miR-125b-5p in PE cases;
(iv) downregulation of miR-100-5p, miR-125b-5p, miR-146a-5p, miR-199a-5p, miR-221-3p, miR-574-3p in FGR cases;
(v) downregulation of miR-100-5p, miR-125b-5p, miR-199a-5p in patients with GH |
| | Mouillet et al., 2010 [47] | Case-control | 14 FGR, 14 HP (controls) | RT-qPCR | Maternal plasma/serum | (i) No differences were found in the level of individual miRNA (miR-27a, miR-30d, miR-141, miR-200c, miR-424, miR-205 and miR-451, miR-491, miR-517a, miR-518b, miR-518e, miR-524) in FGR and HP cases;
(ii) When considered as a group, the level of all tested miRNA species was elevated in plasma samples from women with FGR compared to controls |
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