Research Article

Mortality and Cardiovascular Complications in Older Complex Chronic Patients with Type 2 Diabetes

Table 1

Baseline characteristics of CCP with and without diabetes.

CCP patientsNo diabetesDiabetes

(%)438 (47.00%)494 (53.00%)
Age (average ± SD)84.22 ± 10.681.16 ± 8.0<0.001
Percentage >80 years old 
(%)
340 (77.6%)315 (63.8%)<0.001
Women (%)236 (53.9%)252 (51.0%)0.394
CCP criteria number (average ± SD)3.85 ± 1.263.86 ± 1.120.955
Hypertension (%)362 (80.4%)422 (85.4%)0.044
Dyslipidemia (%)195 (44.5%)326 (66.0%)<0.001
Atrial fibrillation (%)176 (40.2%)149 (30.2%)0.002
Ischaemic cardiopathy (%)87 (19.9%)109 (22.1%)0.422
Peripheral artery disease 
(%)
58 (13.2%)91 (18.4%)0.032
Chronic kidney insufficiency < 30 mlClCr43 (9.8%)73 (14.7%)0.042
Heart failure (%)153 (34.9%)150 (30.4%)0.142
Charlson score 
(average ± SD)
2.05 ± 1.302.95 ± 1.300.015
Stroke before CCP (%)104 (23.7%)96 (19.4%)0.111
Stroke after CCP (%)36 (8.2%)30 (6.1%)0.249
score (average ± SD)5.97 ± 2.387.14 ± 5.97<0.001
HAS_BLED score 
(average ± SD)
2.88 ± 1.143.10 ± 1.050.077
Daily medications number (average ± SD)7.8 ± 3.299.80 ± 3.60<0.001
Polypharmacy ≥ 4 (%)392 (89.5%)484 (98%)<0.001
Polypharmacy ≥ 10 (%)142 (32.4%)258 (52.2%)<0.001
Cognitive impairment (%)179 (40.9%)159 (32.2%)0.006
Pfeiffer test score 
(average ± SD)
3.43 ± 3.392.72 ± 3.130.001
Barthel score (average ± SD)62.8 ± 32.4169.02 ± 31.280.003
Barthel score < 60 (%)182 (41.6%)161 (32.6%)0.005
Fall risk (%)103 (23.9%)85 (17.2%)0.018
Gijón score (average ± SD)9.53 ± 5.1210.46 ± 3.870.363
Antiaggregant treatment 
(%)
147 (33.6%)238 (48.2%) <0.001
Anticoagulant treatment 
(%)
147 (33.6%)123 (24.9%)0.003
Statin treatment (%)149 (34.0%)274 (55.5%)<0.001
Proton pump inhibitor treatment (%)285 (65.1%)358 (72.5%)0.016
Selective serotonin reuptake inhibitors (SSRIs) (%)131 (29.9%)149 (30.2%)0.943
CNS depressant drugs (%)249 (56.8%)265 (53.6%)0.356
Death (%)157 (35.8%)162 (32.8%)0.334