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BioMed Research International
Volume 2017 (2017), Article ID 6087676, 8 pages
Research Article

Parathyroid Hormone (1-34) Might Not Improve Early Bone Healing after Sinus Augmentation in Healthy Rabbits

1Department of Advanced General Dentistry, College of Dentistry, Yonsei University, Seoul, Republic of Korea
2Department of Periodontology, College of Dentistry, Yonsei University, Seoul, Republic of Korea
3Department of Oral Pathology, College of Dentistry, Yonsei University, Seoul, Republic of Korea

Correspondence should be addressed to Wonse Park

Received 21 November 2016; Revised 6 January 2017; Accepted 18 January 2017; Published 9 February 2017

Academic Editor: Rui Liu

Copyright © 2017 Jisun Huh et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Purpose. This study evaluated the effect of administering intermittent parathyroid hormone [PTH (1-34), henceforth PTH] on the early-stage bone healing of maxillary sinus augmentation in healthy rabbits. Materials and Methods. Bovine bone mineral was grafted on the sinuses of 20 female New Zealand white rabbits. The animals were randomly divided into two groups, PTH () or saline (), in which either PTH or saline was injected subcutaneously 5 days a week for 2 weeks. Half of the animals in each group were killed at 2 weeks postoperatively and the other half were killed at 4 weeks postoperatively. The dosage of PTH was 10 μg/kg/day. Radiographic and histomorphometric analyses were performed. Result. The new bone area (NBA) did not differ significantly between the PTH and saline groups. The NBA in the PTH group in the total augmented area and in the demarcated window, center, and Schneiderian membrane regions increased significantly from 2 to 4 weeks. The number of osteoclasts decreased significantly from 2 to 4 weeks in both groups, with no difference between the two groups. Conclusion. Intermittent PTH might not stimulate new bone formation in healthy rabbits during the first 4 weeks of healing.