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BioMed Research International
Volume 2017, Article ID 6096134, 12 pages
Review Article

Advancements in Developing Strategies for Sterilizing and Functional HIV Cures

1Key Laboratory of Medical Molecular Virology of Ministries of Education and Health, School of Basic Medical Sciences and Shanghai Public Health Clinical Center, Fudan University, Shanghai 200032, China
2Key Laboratory of Reproduction Regulation of NPFPC, SIPPR, IRD, Fudan University, Shanghai 200032, China
3Lindsley F. Kimball Research Institute, New York Blood Center, New York, NY 10065, USA

Correspondence should be addressed to Shibo Jiang; nc.ude.naduf@gnaijobihs and Lu Lu; nc.ude.naduf@lul

Received 22 January 2017; Accepted 4 April 2017; Published 26 April 2017

Academic Editor: Himanshu Garg

Copyright © 2017 Wei Xu et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Combined antiretroviral therapy (cART) has been successful in prolonging lifespan and reducing mortality of patients infected with human immunodeficiency virus (HIV). However, the eradication of latent HIV reservoirs remains a challenge for curing HIV infection (HIV cure) because of HIV latency in primary memory CD4+ T cells. Currently, two types of HIV cures are in development: a “sterilizing cure” and a “functional cure.” A sterilizing cure refers to the complete elimination of replication-competent proviruses in the body, while a functional cure refers to the long-term control of HIV replication without treatment. Based on these concepts, significant progress has been made in different areas. This review focuses on recent advancements and future prospects for HIV cures.