Review Article

Autologous Stem Cells Combined Core Decompression for Treatment of Avascular Necrosis of the Femoral Head: A Systematic Meta-Analysis

Table 1

Characteristics of the included studies in the meta-analysis.

StudySample
size (hips)
Age
(years)
Diagnostic
criteria
Disease
stages (hips)
Etiological factors
(hips)
InterventionOutcomeFollow-up (months)
Median

Rastogi et al., 2013 [30]E: NA (30) E: ARCOI/II/IIIE: S (10), A (2), I (14), Sm (4)  E: CD + BMSCs CFH, CT24
C: NA (30)C: C: S (8), A (6), I (12), Sm (4)C: CD + UBM
Pepke et al., 2016 [31]E: NA (11) E: ARCOIINAE: CD + BMSCs CFH, CT24
C: NA (14)C: C: CD
Sen et al., 2012 [32]E: NA (26)  NAARCOI/II (NA)Tr (17), S (20), A (8)  E: CD + BMSCs Harris24
C: NA (25)I (2), P (2), Cs (2)C: CD
Tabatabaee et al., 2015 [33]E: 14 (14)  E: ARCOE: I (3), II (9), III (2)  E: S (10), I (4)  E: CD + BMSCs CFH, CT24
C: 13 (14)C: C: I (2), II (7), III (5)C: S (9), I (5)C: CD
Zhao et al., 2012 [34]E: 50 (53)E: ARCOE: IC (3), IIA (15), IIB (24), IIC (11)E: Tr (8), S (11), A (11), Cd (6), I (17)E: CD + BMSCsCFH, CT60
C: 50 (51)C: C: IC (2), IIA (15), IIB (22), IIC (12)C: Tr (12), S (13), A (8), Cd (5), I (13)C: CD
Ma et al., 2014 [35]E: 21 (25)  E: FicatE: I (3), II (17), III (5)  E: S (15), A (4), I (6)  E: CD + ABG + BMSCs CFH, CT24
C: 18 (24)C: C: I (4), II (15), III (5)C: S (15), A (3), I (6)C: CD + ABG
Guo et al., 2008 [36]E: 10 (12)  42 (28~61)ARCOIII (24)S (7), A (4), Tr (3), U (6)E: CD + BMSCs Harris, PMN12
C: 10 (12)C: CD
Zhao et al., 2016 [37]E: 18 (NA)  20~42 (30.5)SteinbergNANAE: CD + BMSCs + ABG Harris, PMN, CFH24
C: 18 (NA)C: CD + ABG
Yang et al., 2015 [38]E: 30 (44)  E: 16~45 (35.3)  ARCOE: I (16), II (28)  Tr (6), S (36), A (38), U (2)E: CD + BMSCs Harris, PMN, CFH, CT18
C: 26 (38)C: 18~46 (37.6)C: I (16), II (22)C: CD
Sun et al., 2008 [39]E: 15 (17)  17~47 (36)ARCOI (8), II (24)Tr (7), S (9), A (10), U (2)E: CD + BMSCs Harris, CFH, CT18
C: 13 (15)C: CD
Chang et al. 2010 [40]E: 8 (8)19~43 (35.7)ARCOE: IIA (2), IIB (2), IIC (3), IIIA (1)  S (2) A (3) U (3)E: CD + BMSCsHarris, PMN, CFH12
C: 8 (8)C: IIA (4), IIB (2), IIC (1), IIIA (1)C: CD

Note. E: experiment group. C: control group. S: steroids. A: alcohol abuse. Tr: trauma. I: idiopathic. P: pregnancy. Cs: Cushing. Cd: caisson disease. Sm: smoking. U: unknown aetiology. ARCO: Association Research Circulation Osseous. CD: core decompression. BMSCs: bone marrow stem cells. UBM: unprocessed bone marrow. ABG: autologous bone grafting. PMN: postoperation MRI necrosis area. CFH: collapse of the femoral head. CT: conversion to THR. NA: not available.