The Interaction of Selectins and PSGL-1 as a Key Component in Thrombus Formation and Cancer Progression

Figure 3

Quantity of fibrin deposition in the lungs. The western blot analysis of lung extracts shows remarkable difference. (a) Lane 1: fibrinogen standard, lane 2: fibrin standard, lane 3: wild-type mice treated with saline, lane 4: wild-type mice treated with collagen and epinephrine, lane 5: knockout mice treated with saline, and lane 6: knockout mice treated with collagen and epinephrine. (b) After thrombotic challenge, twice as much fibrin deposits were found in the wild-type mice compared to knockout animals (reprinted from Thrombosis Research with permission by Elsevier).

(a)

(b)