Andrographolide Inhibits Proliferation and Metastasis of SGC7901 Gastric Cancer Cells

Figure 1

ANDR inhibited proliferation and induced apoptosis in SGC 7901 cells. (a) ANDR at different concentrations inhibited proliferation of SGC 7901 cells. ANDR-treated groups at 40 μg/ml, 20 μg/ml, and 10 μg/ml had a higher capacity of inhibition on the proliferation of gastric cancer cells than the DMSO-treated groups (control) at 5 μg/ml and 2.5 μg/ml (). There were no significant differences among the DMSO group treated at 2.5 μg/ml and 5 μg/ml. (b) High dosage (H), middle dosage (M), and low dosage (L) ANDR treatment induced apoptosis of SGC 7901 cells. The ratio of apoptotic cells in H group was higher than that of other groups (). The ratio of apoptotic cells in M group was higher than L and N (control) groups (). There was no significant difference between N group and L group.After 48 h, the proliferation of groups at 10 μg/mL, 20 μg/mL, and 40 μg/mL of ANDR was inhibited significantly compared to control group (DMSO group) and groups of 2.5 μg/mL and 5 μg/mL of ANDR.

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