Andrographolide Inhibits Proliferation and Metastasis of SGC7901 Gastric Cancer Cells

Figure 7

Relative expression of genes associated with invasion and apoptosis of cancer cells. ANDR could have an impact on the expression of genes involved in apoptosis, invasion, and survival. Bik, Bax, and Bcl-2 have roles in apoptosis. Proapoptosis genes, Bik and Bax, were upregulated and antiapoptosis gene, Bcl-2, was downregulated after stimulation by ANDR. Meanwhile, survivin, a gene for sustaining cell survival, was also downregulated after ANDR treatment. TIMP-1, TIMP-2, MMP-2, MMP-9, and CD147 are a cluster of genes involved in cellular invasion, including degradation of extracellular matrix components, digestion of basement membrane, and sustaining cell survival. TIMP-1/2 was significantly upregulated while MMP-2/9 and CD147 was downregulated in GC cells after incubation with ANDR for 48 h.