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BioMed Research International
Volume 2017, Article ID 6302869, 6 pages
Research Article

Effect of Excess Iodide Intake on Salivary Glands in a Swiss Albino Mice Model

1Instituto de Biotecnología Farmacéutica y Alimentaria (INBIOFAL-CONICET), Tucumán, Argentina
2Facultad de Ciencias de la Salud, Universidad del Norte Santo Tomás de Aquino (UNSTA), Tucumán, Argentina
3Facultad de Agronomía y Zootecnia, Universidad Nacional de Tucumán, Tucumán, Argentina
4Centro de Referencia para Lactobacilos (CERELA-CONICET), Tucumán, Argentina
5Facultad de Medicina, Universidad Nacional de Tucumán, Tucumán, Argentina

Correspondence should be addressed to Paola Gauffin Cano; ra.gro.alerec@niffuagp

Received 4 May 2017; Revised 16 August 2017; Accepted 15 October 2017; Published 8 November 2017

Academic Editor: Yujiang Fang

Copyright © 2017 Gloria Romina Ross et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Iodine is an important micronutrient required for nutrition. Excess iodine has adverse effects on thyroid, but there is not enough information regarding its effect on salivary glands. In addition to food and iodized salt, skin disinfectants and maternal nutritional supplements contain iodide, so its intake could be excessive during pregnancy, lactation, and infancy. The aim of this work was to evaluate the effect of excess iodide ingestion on salivary glands during mating, gestation, lactation, and postweaning period in mouse. During assay, mice were allocated into groups: control and treatment groups (received distilled water with NaI 1 mg/mL). Water intake, glandular weight, and histology were analyzed. Treatment groups showed an increase in glandular weight and a significantly ( < 0.05) higher water intake than control groups. Lymphocyte infiltration was observed in animals of treatment groups, while there was no infiltration in glandular sections of control groups. Results demonstrated that a negative relationship could exist between iodide excess and salivary glands. This work is novel evidence that high levels of iodide intake could induce mononuclear infiltration in salivary glands. These results should be considered, especially in pregnant/lactating women, to whom a higher iodine intake is usually recommended.