Contribution of Inhibitor of DNA Binding/Differentiation-3 and Endocrine Disrupting Chemicals to Pathophysiological Aspects of Chronic Disease

Figure 2

(a) ID3 molecular mechanism and vascular diseases. Summary illustration of ID3 signaling involved in vascular disease pathogenesis. ID3 signaling can lead to neointimal lesions or vascular remodeling by transcriptional regulation of the target genes described above (up- and down regulated genes by ID3)

(b) ID3 involvement in arteriovenous malformation. Summary of experimental studies showing impact of ID3 in vascular cell dysfunction