Autophagy Protects Advanced Glycation End Product-Induced Apoptosis and Expression of MMP-3 and MMP-13 in Rat Chondrocytes

Figure 1

AGEs inhibit cell viability and increase levels of MMP-3 and MMP-13 in chondrocytes. (a) Cell viability assay. Chondrocytes were treated with the indicated dose of AGEs and BSA for 24 h. Cell viability was measured by the CCK-8 assay. (b) Western blot analysis of MMP-3 and MMP-13 after incubating chondrocytes with different concentrations of AGEs for 24 h. (c, d) Protein densitometric quantification of MMP-3 and MMP-13. Dates are presented as the mean ± SD of at least three independent experiments. and versus the control group.

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