Bioinformatics Genes and Pathway Analysis for Chronic Neuropathic Pain after Spinal Cord Injury

Table 3

The top 10 altered pathways of network analyses. The outdegree and indegree represent, respectively, the number of upstream and downstream signal pathways. The degree represents the sum of the outdegree and indegree. In the top 10 altered pathway interaction nets with 111 nodes and 404 relationships between each other, MAPK signaling pathway was the most important one with the largest degree (outdegree = 5, indegree = 39, and degree = 44).

Pathway ID	Pathway name	Outdegree	Indegree	Degree	Rank
4010	MAPK signaling pathway	5	39	44	1
4210	Apoptosis	3	29	32	2
5200	Pathways in cancer	28	0	28	3
4110	Cell cycle	3	20	23	4
10	Glycolysis/gluconeogenesis	5	15	20	5
4020	Calcium signaling pathway	5	14	19	6
4115	p53 signaling pathway	2	17	19	7
4310	Wnt signaling pathway	8	9	17	8
4060	Cytokine-cytokine receptor interaction	0	16	16	9
620	Pyruvate metabolism	7	8	15	10