Review Article

Bioinformatics Genes and Pathway Analysis for Chronic Neuropathic Pain after Spinal Cord Injury

Table 5

Top 10 DEGs and pathways between sham-injury and injury in different sections. By processing data from all time points in each section, top 10 DEGs and pathways between sham-injury and injury are showed, respectively.

SectionTop 10 DEGs between sham-injury and injuryTop 10 pathways between sham-injury and injury

rostral regionsCcl3, Plek, Slc15a3, Bcl2a1a, Plek, Tlr2, Ccl4, Clec7a, Plek, PalldOsteoclast differentiation, cytokine-cytokine receptor interaction, PI3K-Akt signaling pathway, phagosome, Chagas disease (American trypanosomiasis), leishmaniasis, toll-like receptor signaling pathway, chemokine signaling pathway, tuberculosis, transcriptional misregulation in cancer

lesion centreCcl3, Atf3, Plek, Ctla2b, Bcl2a1a, Ch25h, Plek, Tnfaip3, Tgif1, Gpr84MAPK signaling pathway, metabolic pathways, PI3K-Akt signaling pathway, pathways in cancer, osteoclast differentiation, HTLV-I infection, regulation of actin cytoskeleton, chemokine signaling pathway, Focal adhesion, proteoglycans in cancer

caudal regionsAtf3, Tlr2, Irgm1, Trim30d, S1pr3, Bcl2a1a, Slc45a3, Plek, Trim30a, Zfp36l1Tuberculosis, phagosome, Staphylococcus aureus infection, leishmaniasis, osteoclast differentiation, antigen processing and presentation, herpes simplex infection, Fc gamma R-mediated phagocytosis, viral myocarditis, Toll-like receptor signaling pathway