Comparison of Host Gene Expression Profiles in Spleen Tissues of Genetically Susceptible and Resistant Mice during ECTV Infection
Table 2
List of 10 DEGs that were most up- or downregulated in BALB/c and C57BL/6 during ECTV infection.
Mouse strain
BALB/c
C57BL/6
After infection
3 dpi versus uninfected
10 dpi versus uninfected
3 dpi versus uninfected
10 dpi versus uninfected
Gene category
Gene
Fold change
Gene
Fold change
Gene
Fold change
Gene
Fold change
Upregulated
Kap
5.65
Spp1
46.2
Xist
27.28
Xist
50.37
Hspa1b
4.39
Gzmb
39.4
Ttr
4.49
Hspa1b
26.23
Gbp1
4.32
Ifng
24.2
Tsks
3.13
Gzmb
22.26
Gdi2
3.99
Vcan
20.7
Mettl11a
2.93
Gbp1
17.84
Apol7c
3.95
Mmp3
17.9
Hspa1b
2.81
Hspa1a
15.25
Slfn4
3.60
Nts
16.5
Ptger1
2.68
Ctsg
14.02
Gbp2
3.57
Timp1
14.0
Alb
2.59
Mcpt8
10.06
Ddx6
3.47
Gzmd
13.6
Ifnz
2.34
Rgs1
8.74
Iigp1
3.42
Saa3
13.6
Dppa5a
2.32
Gzmk
7.71
Acaa2
3.41
Cxcl5
12.6
Cml3
2.29
Prtn3
7.03
Downregulated
Vmn1r148
0.33
Ctrb1
0.08
Psap
0.29
Bpgm
0.17
Phxr5
0.33
Try4
0.02
Cyp4f16
0.28
Dbp
0.17
Reg2
0.32
Cpb1
0.03
Foxp1
0.28
Igfbp5
0.17
Psg28
0.29
Cela3b
0.03
Epsti1
0.28
Ccr9
0.16
Mup10
0.28
Marco
0.03
Abhd12
0.27
Apol7c
0.16
Astx
0.25
Clps
0.04
Kap
0.27
Kdm5d
0.16
Adipoq
0.25
Zg16
0.05
Tpm3
0.26
Cyr61
0.15
Cfd
0.16
Emr4
0.06
Ddx3y
0.25
Ddx3y
0.14
Car3
0.08
Pnlip
0.02
Sh3bgrl
0.25
Eif2s3y
0.13
Mettl11a
0.06
Amy2a1
0.006
Hmgcs1
0.22
Igfbp3
0.12
The DEGs were ranked by fold change and those were the most (fold change) up- or downregulated in expression at 3 and 10 dpi in BALB/c and C57BL/6 mice.