Comparison of Host Gene Expression Profiles in Spleen Tissues of Genetically Susceptible and Resistant Mice during ECTV Infection

Table 2

List of 10 DEGs that were most up- or downregulated in BALB/c and C57BL/6 during ECTV infection.

Mouse strain	BALB/c				C57BL/6
After infection	3 dpi versus uninfected		10 dpi versus uninfected		3 dpi versus uninfected		10 dpi versus uninfected
Gene category	Gene	Fold change	Gene	Fold change	Gene	Fold change	Gene	Fold change
Upregulated	Kap	5.65	Spp1	46.2	Xist	27.28	Xist	50.37
	Hspa1b	4.39	Gzmb	39.4	Ttr	4.49	Hspa1b	26.23
	Gbp1	4.32	Ifng	24.2	Tsks	3.13	Gzmb	22.26
	Gdi2	3.99	Vcan	20.7	Mettl11a	2.93	Gbp1	17.84
	Apol7c	3.95	Mmp3	17.9	Hspa1b	2.81	Hspa1a	15.25
	Slfn4	3.60	Nts	16.5	Ptger1	2.68	Ctsg	14.02
	Gbp2	3.57	Timp1	14.0	Alb	2.59	Mcpt8	10.06
	Ddx6	3.47	Gzmd	13.6	Ifnz	2.34	Rgs1	8.74
	Iigp1	3.42	Saa3	13.6	Dppa5a	2.32	Gzmk	7.71
	Acaa2	3.41	Cxcl5	12.6	Cml3	2.29	Prtn3	7.03
Downregulated	Vmn1r148	0.33	Ctrb1	0.08	Psap	0.29	Bpgm	0.17
	Phxr5	0.33	Try4	0.02	Cyp4f16	0.28	Dbp	0.17
	Reg2	0.32	Cpb1	0.03	Foxp1	0.28	Igfbp5	0.17
	Psg28	0.29	Cela3b	0.03	Epsti1	0.28	Ccr9	0.16
	Mup10	0.28	Marco	0.03	Abhd12	0.27	Apol7c	0.16
	Astx	0.25	Clps	0.04	Kap	0.27	Kdm5d	0.16
	Adipoq	0.25	Zg16	0.05	Tpm3	0.26	Cyr61	0.15
	Cfd	0.16	Emr4	0.06	Ddx3y	0.25	Ddx3y	0.14
	Car3	0.08	Pnlip	0.02	Sh3bgrl	0.25	Eif2s3y	0.13
	Mettl11a	0.06	Amy2a1	0.006	Hmgcs1	0.22	Igfbp3	0.12

The DEGs were ranked by fold change and those were the most (fold change) up- or downregulated in expression at 3 and 10 dpi in BALB/c and C57BL/6 mice.