Effects of Pirfenidone and Collagen-Polyvinylpyrrolidone on Macroscopic and Microscopic Changes, TGF-β1 Expression, and Collagen Deposition in an Experimental Model of Tracheal Wound Healing

Figure 2

Micrograph of tracheal wound healing stained with Masson’s trichrome (40x magnification). (a) Moderate inflammation and moderate amount of disorganized, thick collagen fibers in group I. (b) Mild inflammation and minimal number of organized, thick collagen fibers in the Collagen-PVP group. (c) Moderate inflammation and fibrosis with a moderate amount of disorganized, thin collagen fibers in animals from group III. (d) Tracheal wound free of inflammation and few organized, thin collagen fibers in the group treated with PFD.

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