Effects of Pirfenidone and Collagen-Polyvinylpyrrolidone on Macroscopic and Microscopic Changes, TGF-β1 Expression, and Collagen Deposition in an Experimental Model of Tracheal Wound Healing

Figure 3

Photomicrographs of immunohistochemical detection of TGF-β1 in tracheal scar (40x), showing strong TGF-β1 expression (dark brown immunostaining) in the SS (a) and MMC (c) groups, in contrast to weak TGF-β1 expression (light brown immunostaining) in animals treated with Collagen-PVP (b) and PFD (d).

(a)

(b)

(c)

(d)