Effects of Pirfenidone and Collagen-Polyvinylpyrrolidone on Macroscopic and Microscopic Changes, TGF-β1 Expression, and Collagen Deposition in an Experimental Model of Tracheal Wound Healing

Table 1

Amount of animals with macroscopic changes in each study group.

Amount of animals with macroscopic findings at the end of study
	Group I; SS	Group II; Collagen-PVP	Group III; MMC	Group IV; PFD
Wound dehiscence or infection	0	0	0	0
Mild inflammation	0		0
Moderate inflammation	10	0	8	0
Severe inflammation	0	0	2	0
Mild fibrosis	0		0
Moderate fibrosis	10	0	8	0
Severe fibrosis	0	0	2	0
Mild edema	0	0		0
Severe decrease of tracheal lumen	0	0	2	0

, Kruskal-Wallis).