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BioMed Research International
Volume 2017 (2017), Article ID 6482842, 7 pages
https://doi.org/10.1155/2017/6482842
Research Article

Leptin-LepRb Expressed in Gastric Cancer Patients and Related to Cancer-Related Depression

1Department of Laboratory Medicine, Zhongnan Hospital of Wuhan University, Wuhan, Hubei 430071, China
2Department of Hematology, Zhongnan Hospital of Wuhan University, Wuhan, Hubei 430071, China
3Department of Clinical Oncology, The First Affiliated Hospital, Xi’an Jiaotong University, Xi’an 710061, China
4Department of Clinical Laboratory, The First Affiliated Hospital, Xi’an Jiaotong University, Xi’an 710061, China
5Department of Radiation and Medical Oncology, Zhongnan Hospital of Wuhan University, Wuhan, Hubei 430071, China

Correspondence should be addressed to Yongchang Wei; moc.361@8gnahcgnoyiew

Received 28 October 2016; Revised 12 January 2017; Accepted 22 January 2017; Published 20 February 2017

Academic Editor: Koichiro Wada

Copyright © 2017 Yunbao Pan et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Depression is the most common psychiatric disorder among cancer patients. Studies have not only highlighted that leptin and its receptor (LepRb) are independent poor prognostic factors in gastric cancer (GC) patients but also shown that the leptin-LepRb is necessary for antidepressant-like behaviors. In this study, we examined the serum and tissue leptin-LepRb expression in GC patients. Enzyme-linked immunosorbent assay showed that depressive GC patients had significantly higher serum leptin-LepRb than healthy donors. Leptin-LepRb levels in GC tissues were also significantly higher than in matched paracarcinoma tissues using real-time RT-PCR. Moreover, we observed that both serum and tissue leptin-LepRb were significantly higher in depressive GC patients than those in nondepressive GC patients. Further, the patients with high tumor stage tend to have higher leptin-LepRb mRNA levels than that with low tumor stage. Together, our findings suggest that leptin-LepRb plays an important role in the pathogenesis and depression in GC. Leptin-LepRb therefore could be a potential diagnostic marker and therapeutic target in GC patients with depression.