MicroRNA-Related Polymorphisms in PI3K/Akt/mTOR Pathway Genes Are Predictive of Limited-Disease Small Cell Lung Cancer Treatment Outcomes

Table 4

RPA classification based on unfavorable genotype combinations.

	rs3756668	rs2536		5y-OS	HR (95% CI) adjusted	adjusted	HR (95% CI) bootstrap	bootstrap
Low risk	AA	Any	25	47.7%	Ref	0.004	Ref
Intermediate risk	GA + GG	TT	96	40.8%	2.163 (0.963–4.866)	0.062	2.210 (2.154–2.268)
High risk	GA + GG	TC	21	17.6%	4.535 (1.813–11.345)	0.001	4.539 (4.409–4.673)

Adjusted for age, gender, Karnofsky performance score (KPS), smoking history, and Charlson comorbidity index (CCI).
RPA: recursive partitioning analysis; OS: overall survival; HR: hazard ratio; CI: confidence interval.