The Effects of Formaldehyde on Cytochrome P450 Isoform Activity in Rats

Table 2

Main pharmacokinetic parameters of probe drugs in rats treated with formaldehyde (FA) ( per group, mean ± SD).

Probe drug name	Parameter	Control group	Low dose FA	High dose FA
Phenacetin	(min)	163.89 ± 12.32	110.24 ± 13.19	92.42 ± 8.34
	CL (L/h/kg)	0.44 ± 0.11	0.61 ± 0.13	0.85 ± 0.09
	(L/kg)	105.07 ± 9.78	96.51 ± 8.90	81.5 ± 7.89
	(mg/mLmin)	87.86 ± 8.56	71.7 ± 7.65	42.98 ± 6.09
	(mg/L)	543.90 ± 35.06	614.13 ± 50.69	359.81 ± 31.24
Tolbutamide	(min)	176.53 ± 16.76	181.24 ± 18.67	197.51 ± 16.45
	CL (L/h/kg)	0.01 ± 0.003	0.01 ± 0.002	0.01 ± 0.003
	(L/kg)	9.09 ± 1.62	10.10 ± 1.31	13.98 ± 1.33
	(mg/mLmin)	1481.73 ± 177.98	1592.93 ± 182.08	1660.67 ± 117.98
	(mg/L)	6740.54 ± 289.07	7001.56 ± 302.01	7469.93 ± 346.78
Chlorzoxazone	(min)	124.93 ± 16.43	133.92 ± 11.53	151.03 ± 11.90
	CL (L/h/kg)	0.23 ± 0.04	0.20 ± 0.05	0.16 ± 0.03
	(L/kg)	41.16 ± 2.34	50.58 ± 3.55	57.32 ± 3.13
	(mg/mLmin)	186.9 ± 12.34	216.75 ± 18.78	261.21 ± 21.33
	(mg/L)	1063.40 ± 122.30	1167.62 ± 119.87	1381.03 ± 130.52
Testosterone	(min)	80.27 ± 8.45	89.73 ± 10.09	92.91 ± 9.98
	CL (L/h/kg)	1.16 ± 0.12	1.11 ± 0.21	0.87 ± 0.18
	(L/kg)	218.66 ± 18.76	213.40 ± 13.32	209.68 ± 12.78
	(mg/mLmin)	37.85 ± 4.32	42.20 ± 3.22	52.91 ± 2.76
	(mg/L)	391.24 ± 21.17	423.92 ± 26.74	465.39 ± 30.49

Significantly different from control, .
Significantly different from control, .