Multivalent Fusion DNA Vaccine against Brucella abortus

Table 1

Protection conferred by multivalent DNA vaccines in BALB/c mice challenged with the pathogenic B. abortus 2308 strain.

Experimental groups ()	Log10 CFU of Brucella abortus 2308 per spleen (means ± SD)	Log10 units of
PBS	4.98 ± 0.09	0
pVAX	4.92 ± 0.06	0
pV273-sod	4.58 ± 0.07	0.40
pV278-sod	4.66 ± 0.18	0.32
pV273-278-sod	4.7 ± 0.23	0.28
B. abortus strain RB51	4.04 ± 0.25

of protection represent the difference between the mean ± SD of Log₁₀ CFU values of the PBS control group and log10 CFU values of the immunized group. All animals were challenged with B. abortus 2308 strain and bacterial counts were assessed at day 15. < 0.05 indicates statistically significant values..