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BioMed Research International
Volume 2017, Article ID 6705363, 9 pages
https://doi.org/10.1155/2017/6705363
Review Article

The Effect of Granulocyte Colony-Stimulating Factor on the Progression of Atherosclerosis in Animal Models: A Meta-Analysis

1Department of Pathology and Key Laboratory of Xinjiang Endemic and Ethnic Diseases, Ministry of Education, Shihezi University School of Medicine, Shihezi, Xinjiang, China
2Department of Pathology, The First Affiliated Hospital to Shihezi University School of Medicine, Shihezi, Xinjiang, China
3Department of Cardiology, The First Affiliated Hospital to Shihezi University School of Medicine, 45 North 3rd Road, Shihezi, Xinjiang, China
4Department of Cardiology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, 1095 Jiefang Avenue, Wuhan, China
5Department of Orthopaedics, Shihezi University School of Medicine, 45 North 3rd Road, Shihezi, Xinjiang, China

Correspondence should be addressed to Weishan Wang; moc.361@77623997631m and Lijuan Pang; moc.361@654321naeco

Received 1 January 2017; Accepted 12 July 2017; Published 12 September 2017

Academic Editor: Louise Bennett

Copyright © 2017 Manli Liu et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Background. Atherosclerosis is a common inflammatory disease. Stem cell and endothelial progenitor cell treatments can improve cardiac function after myocardial infarction. Granulocyte colony-stimulating factor (G-CSF) is a mobilisation agent, mobilising stem cells from the bone marrow to circulation in the blood. G-CSF may constitute a treatment of atherosclerosis. We have conducted meta-analysis to evaluate the current evidence for the effect of G-CSF on the progression of atherosclerosis in animal models and to provide reference for preclinical experiments and future human clinical trials of atherosclerosis treatment. Methods. We searched several databases and conducted a meta-analysis across seven articles using a random-effect model. All statistical analyses were performed using Review Manager Version 5.2 and Stata 12.0. Results. We found that G-CSF therapy was associated with reduced atherosclerotic lesion area (weighted mean difference (WMD): 7.29%; 95% confidence interval (CI): 2.06–12.52%; ). No significant differences in total serum cholesterol () and triglyceride levels () were noted in G-CSF treatment groups compared with controls. Multivariable metaregression analysis revealed that the animal type (rabbit, ) and frequency of G-CSF administration (>20, ) impacted the atherosclerotic lesion area changes. Conclusion. The meta-analysis suggested that G-CSF treatment might inhibit the progression of atherosclerosis in animal models.