The Effect of Granulocyte Colony-Stimulating Factor on the Progression of Atherosclerosis in Animal Models: A Meta-Analysis

Table 1

Characteristics of the studies.

First author (year)		Diet	Animal model	Delivery route	G-CSF dose	Total number of injections	Time point of atherosclerotic lesion area measurement
Haghighat (2007)	7; 7	Low-fat; Atherogenic	Mouse; Mouse	Hypodermic	10 μg/kg/d; 10 μg/kg/d	20; 20	8 weeks; 8 weeks
Hasegawa (2006)	7	Not reported	Rabbit	Hypodermic	100 μg/kg/d	7	4 weeks
Matsumoto (2010)	7; Or; 8	Atherogenic	Rabbit	Hypodermic	50 μg/kg/d; 100 μg/kg/d; 300 μg/kg/d; 100 μg/kg/d	5; 5; 5; 15	12 weeks; 12 weeks; 12 weeks; 12 weeks
Sinha (2014)	9	Atherogenic	Mouse	Intraperitoneal injection	300 μg/kg/d	45	9 weeks
Su (2009)	13; or; 11	Atherogenic	Mouse	Hypodermic	10 μg/animal/d	63	9 weeks
Tousoulis (2013)	10	Atherogenic	Mouse	Intravenous	100 μg/kg/d	7	6 weeks
Uchiyama (2012)	10	Atherogenic	Mouse	Hypodermic	200 μg/kg/d	20	4 weeks
Zhao (2006)	8	Atherogenic	Rabbit	Hypodermic	50 μg/animal/d	84	12 weeks

G-CSF, granulocyte colony-stimulating factor. Time from the beginning of treatment.