BioMed Research International / 2017 / Article / Tab 1

Review Article

The Effect of Granulocyte Colony-Stimulating Factor on the Progression of Atherosclerosis in Animal Models: A Meta-Analysis

Table 1

Characteristics of the studies.

First author (year)DietAnimal modelDelivery routeG-CSF doseTotal number of injectionsTime point of atherosclerotic lesion area measurement

Haghighat (2007)7
7
Low-fat
Atherogenic
Mouse
Mouse
Hypodermic10 μg/kg/d
10 μg/kg/d
20
20
8 weeks
8 weeks

Hasegawa (2006)7Not reportedRabbitHypodermic100 μg/kg/d74 weeks

Matsumoto (2010)7
Or
8
AtherogenicRabbitHypodermic50 μg/kg/d
100 μg/kg/d
300 μg/kg/d
100 μg/kg/d
5
5
5
15
12 weeks
12 weeks
12 weeks
12 weeks

Sinha (2014)9AtherogenicMouseIntraperitoneal injection300 μg/kg/d459 weeks

Su (2009)13
or
11
AtherogenicMouseHypodermic10 μg/animal/d639 weeks

Tousoulis (2013)10AtherogenicMouseIntravenous100 μg/kg/d76 weeks

Uchiyama (2012)10AtherogenicMouseHypodermic200 μg/kg/d204 weeks

Zhao (2006)8AtherogenicRabbitHypodermic50 μg/animal/d8412 weeks

G-CSF, granulocyte colony-stimulating factor. Time from the beginning of treatment.